Study of Glutathione-S-transferase (gstm1 and gstt1) Gene Polymorphisms in Down Syndrome Patients
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چکیده
Downs syndrome(DS), also known as Trisomy 21 is the commonest of congenital anomalies occurring 1 in 800 live births [1]. It is known as one of the most common chromosomal abnormalities. Down syndrome is often the result of lack of proper segregation of chromosomes number 21 during meiosis or in the less frequently in the mitotic phase of the egg cell. By examining artifacts from the Tumaco-La Tolita culture, which existed on the border between current Colombia and Ecuador approximately 2500 years ago [2]. Suspected that certain figurines depicted individuals with Trisomy 21, making these potteries the earliest evidence for the syndrome [3]. Existence of the syndrome is characterized by dysmorphic facies. The incidence of Downs’s syndrome increases as the age of mother increases. The syndrome was first described by Dr. John Langdon Down in 1866 [4]. The human GSTs are a family of enzymes known to act in the body as the defense systems for neutralize free radicals [5]. These protein family members are in the form of dimer [6].
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